姓名：張亞卓   性別：男   職稱：教授

招生類型：科學與專業(yè)學位(碩) 科學與專業(yè)學位(博)

招生專業(yè)：外科學（神外）(碩) 外科學（神外）(博)

研究方向：垂體瘤與顱底脊索瘤的基礎與臨床研究

電子信箱：[email protected]

社會任職

1. 中國醫(yī)師協(xié)會神經(jīng)內(nèi)鏡醫(yī)師培訓學院院長

2. 中國醫(yī)師協(xié)會內(nèi)鏡醫(yī)師分會神經(jīng)內(nèi)鏡專家委員會主任委員

3. 北京醫(yī)學會神經(jīng)外科分會主任委員

4. 中國醫(yī)師協(xié)會神經(jīng)修復學專業(yè)委員會主任委員

5. 首都醫(yī)科大學垂體腺瘤臨床診療與研究中心主任

6. 中國醫(yī)師協(xié)會內(nèi)鏡醫(yī)師分會副會長

7. 《中華神經(jīng)外科雜志》總編輯

8. 世界華人神經(jīng)外科協(xié)會第三屆委員會主席

9. 北京市腦重大疾病研究院腦腫瘤研究所所長

個人簡歷

1. 199704-      :北京市神經(jīng)外科研究所 北京天壇醫(yī)院神經(jīng)外科 主任醫(yī)師

2. 199507-199704:北京市神經(jīng)外科研究所 博士后 副主任醫(yī)師

3. 199208-199507:天津醫(yī)科大學總醫(yī)院神經(jīng)外科 攻讀博士學位

4. 198908-199208:佳木斯醫(yī)學院附屬醫(yī)院神經(jīng)外科 主治醫(yī)師

5. 198608-198908:天津醫(yī)科大學總醫(yī)院 攻讀碩士學位 主治醫(yī)師

6. 198208-198608:佳木斯醫(yī)學院附屬醫(yī)院神經(jīng)外科 住院醫(yī)師

7. 197803-198208:佳木斯醫(yī)學院醫(yī)療系 大學本科

重要學術論文

1. Jing Guo#,Chuzhong Li#,Qiuyue Fang,Yulou Liu,Dawei Wang,Yiyuan Chen,Weiyan Xie*，Yazhuo Zhang*.The SF3B1 R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1.Journal Of Experimental & Clinical Cancer Research.2022.41（1）.26.SCI

2. Jiwei Bai#, Jianxin Shi#, Chuzhong Li #, Shuai Wang#, Tongwu Zhang , Xing Hua, Bin Zhu , Hela Koka, Ho-Hsiang Wu , Lei Song, Difei Wang, Mingyi Wang , Weiyin Zhou,Bari J. Ballew, Bin Zhu, Belynda Hicks , Lisa Mirabello, Dilys M. Parry, Yixuan Zhai, Mingxuan Li, Jiang Du, Junmei Wang, Shuheng Zhang, .Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival.nature communications.2021.12（1）.757.SCI

3. Chuzhong Li#,Weiyan Xie#, Jared S. Rosenblum,Jianyu Zhou, Jing Guo, Yazhou Miao, Yutao Shen, Hongyun Wang, Lei Gong, Mingxuan Li,Sida Zhao, Sen Cheng, Haibo Zhu,Tao Jiang, Shiying Ling, Fei Wang, Hongwei Zhang,Zhengping Zhuang*, Yazhuo Zhang*.Somatic SF3B1 hotspot mutation in prolactinomas .Nature Communications.2021.11(1).2506.SCI

4. Mingxuan Li,Yutao Shen,Yujia Xiong ,Shuai Wang,Chuzhong Li ,Jiwei Bai *,Yazhuo Zhang *.Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5.Cell Proliferation.2021.54(12).13136.SCI

5. Jiwei Bai,Mingxuan Li,Yujia Xiong,Yutao Shen,Chunhui Liu, Peng Zhao, Lei Cao,Songbai Gui,Chuzhong Li*, Yazhuo Zhang*.Proteomics Analysis Identified ASNS as a Novel Biomarker for Predicting Recurrence of Skull Base Chordoma.frontiers in oncology.2021.11.698497.SCI

6. Song G, Qiu J, Li C, Li J, Gui S, Zhu H, Zhang Y*.Alterations of regional homogeneity and functional connectivity in pituitary adenoma patients with visual impairment.Scientific Reports.2017.7(1).-.SCI

7. Wang J, Liu Q, Gao H, Wan D, Li C, Li Z, Zhang Y*.EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway.Tumour Biol.2017.39 (7).-.SCI

8. Wang J, Liu Q, Gao H, Wan D, Li C, Li Z, Zhang Y*.EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway.Tumour Biol.2017.39 (7).-.SCI

9. Weiyan Xie#，Chunhui Liu，Dan Wu, Zhenye Li, Chuzhong Li， and Yazhuo Zhang*.Phosphorylation of kinase insert domain receptor by cyclindependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas.Oncotarget.2016.7.50883-50894.SCI

10. YOUTU WU#, JIWEI BAI, LINCHUAN HONG, CHUNHUI LIU, SHENGYUAN YU, GUOQIANG YU and YAZHUO ZHANG*.Low expression of secreted frizzled.related protein 2 and nuclear accumulation of β.catenin in aggressive nonfunctioning pituitary adenoma.ONCOLOGY REPORTS.2016.12.199-206.SCI

11. Youtu Wu#, Chunhui Liu, Shengyuan Yu, Hua Gao, Zhenye Li, Chuzhong Li and Yazhuo Zhang*.Assessment of sFRP4 as a bio-marker for predicting aggressiveness and recurrence of growth hormone-secreting pituitary adenomas.ONCOLOGY REPORTS.2016.35.2991-2999.SCI

12. Chunhui Liu＃, Hua Gao＃, Lei Cao, Songbai Gui, Qian Liu, Chuzhong Li, Dan Li, Lei Gong, and Yazhuo Zhang＊.The Role of FSCN1 in Migration and Invasion of Pituitary Adenomas.Mol Cell Endocrinol..2016.419.217-24.SCI

13. Hua Gao, Fei Wang, Xiaolei Lan, Chuzhong Li, Jie Feng, Jiwei Bai, Lei Cao, Songbai Gui,Lichuan Hong and Yazhuo Zhang＊.Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas. .BMC TUMOR.2015.15(1).272.SCI

14. Wu Y, Bai J, Li Z, Wang F, Cao L, Liu C, Yu S, Yu G, Zhang Y*.Low expression of secreted frizzled-related protein 4 in aggressive pituitary adenoma.Pituitary.2015.18(3).335-42.SCI

15. Li Z, Liu Q, Li C, Zong X, Bai J, Wu Y, Lan X, Yu G, Zhang Y*.The role of TGF-β/Smad signaling in dopamine agonist-resistant prolactinomas.molecular and cellular endocrinology.2015.402.64-71.SCI

16. Xie W, Wang H, He Y, Li D, Gong L, Zhang Y*.CDK5 and its activator P35 in normal pituitary and in pituitary adenomas: relationship to VEGF expression.Int J Biol Sci.2014.10(2).192-199. .SCI

17. Cao L, Gao H, Gui S, Bai G, Lu R, Wang F, Zhang Y*.Effects of the estrogen receptor antagonist fulvestrant on F344 rat prolactinoma models.J Neurooncol.2014.116(3).523-531.SCI

18. Hong L, Wu Y, Feng J, Yu S, Li C, Wu Y, Li Z, Cao L, Wang F, Zhang Y*.Overexpression of the cell adhesion molecule claudin-9 is associated with invasion in pituitary oncocytomas.human pathology.2014.45（12）.2423-2429.SCI

19. Zhenye L, Chuzhong L, Youtu W, Xiaolei L, Lei C, Lichuan H, Hongyun W, Yonggang W, Fei W, Yazhuo Z*.The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas.journal of translational medicine.2014.12.71.SCI

20. 姜之全，桂松柏，張亞卓*.Analysis of differential gene expression in plurihormonal pituitary adenomas using bead-based fiber-optic arrays.J Neurooncol.2012.108（3）.341-348.SCI

21. 張亞卓 .建立轉(zhuǎn)化醫(yī)學平臺、促進神經(jīng)外科人才培養(yǎng) .中華神經(jīng)外科雜志.2010.26（11）.961-962.核心期刊

22. 裴傲; 張亞卓*; 宗緒毅; 王新生; 趙澎; 宋明;.內(nèi)鏡經(jīng)鼻蝶入路手術治療大型垂體腺瘤. 中國神經(jīng)腫瘤雜志.2009.7(1).22-24.

23. 劉方軍; 張亞卓; 趙澎; 張永力; 孫玉明; 周忠清; 王計強; 石祥恩;.顱內(nèi)血管外膜細胞瘤的臨床診治6例分析及文獻復習 . 中國神經(jīng)腫瘤雜志.2009.7（2).118-121.

24. 李儲忠; 趙澎; 宗緒毅; 桂松柏; 劉方軍; 張亞卓*.單鼻孔內(nèi)鏡下經(jīng)蝶、擴大經(jīng)蝶入路腫瘤切除術術中、術后出血原因分析及對策 .中國神經(jīng)腫瘤雜志 .2009.7（1).33-36.

25. 李儲忠; 張亞卓*.神經(jīng)內(nèi)鏡應用進展 .中國神經(jīng)精神疾病雜志.2009.35（2）.67—68.

26. 桂松柏; 張亞卓*; 王新生; 宗緒毅; 趙澎;.內(nèi)鏡顱底手術后顱內(nèi)感染的綜合治療1例報告 .中國神經(jīng)腫瘤雜志 .2009.7（1).37-38.

27. 宋明1， 張亞卓2*.內(nèi)鏡技術在中樞神經(jīng)系統(tǒng)腫瘤治療中的應用.中國神經(jīng)腫瘤雜志.2009.7(1).1-5.

28. 趙澎1， 桂松柏1， 李儲忠1， 宋明2， 裴傲3， 王新生1， 宗緒毅1， 張亞卓*.神經(jīng)內(nèi)鏡治療腦室內(nèi)腫瘤20 例臨床經(jīng)驗.中國神經(jīng)腫瘤雜志.2009.7(1).7-13.

29. 桂松柏，張亞卓*孫梅珍.氧化損傷星形膠質(zhì)細胞與骨髓基質(zhì)細胞共培養(yǎng)的實驗研究 .中華神經(jīng)醫(yī)學雜志 .2008.7（3）.267-272.

30. 趙澎，張亞卓*.Reversion of nultidrug resistance in human glioma by RNA interference .Neurological Research.2008.30.562~566.

31. 嚴耀華，張亞卓*.三腦室底造瘺中的心率變化.中華神經(jīng)外科雜志.2008.24(3).193-195.

32. 宋明，張亞卓*，王新生，宗緒毅.內(nèi)鏡下經(jīng)鼻入路顯露視神經(jīng)和眼眶的解剖研究.中國內(nèi)鏡雜志.2008.14(4).357-360.

33. 劉方軍，張亞卓*，桂松柏，孫澤林.F90對膠質(zhì)母細胞瘤的作用及機制研究.中國微侵襲神經(jīng)外科雜志.2008.13(5).220-222.

主編或副主編的著作/譯著

1. 《內(nèi)鏡神經(jīng)外科學（第3版）》,主編,人民衛(wèi)生出版社,202211

2. 《神經(jīng)內(nèi)鏡手術規(guī)范化培訓教程》,主編,人民衛(wèi)生出版社,201804

3. 《內(nèi)鏡神經(jīng)外科學（第2版）》,主編,人民衛(wèi)生出版社,201705

4. 《內(nèi)鏡神經(jīng)外科學》,主編,人民衛(wèi)生出版社,201207

5. 《《腦室外科學》》,主編,人民衛(wèi)生出版社,201101

6. 《內(nèi)鏡顱底外科(翻譯版)》,主譯,科學出版社,201003

7. 《神經(jīng)內(nèi)鏡手術技術》,主編,北京大學醫(yī)學出版社,200403

8. 《腦室外科手術學》,主編,中國協(xié)和醫(yī)科大學出版社,200110

重要獎項

1. 顱底內(nèi)鏡技術研發(fā)轉(zhuǎn)化與應用 北京市科技進步二等獎 2012

2. 微侵襲神經(jīng)內(nèi)鏡應用技術的研究 市三等（1） 2003

3. 微侵襲內(nèi)鏡神經(jīng)外科應用技術研究 中華醫(yī)學獎三等 2003

4. 微侵襲內(nèi)鏡神經(jīng)外科應用技術研究 北京市科技技術獎三等獎 2003

5. 腦干腫瘤的基礎與臨床研究 市二等 2000